PROFESSIONAL BACKGROUND
- B.S. 2001, Brigham Young University
- PhD 2006 University of California-Irvine.
COURSE TAUGHT
- Bio10
- Bio112
- Bio220 & lab
- Bio376 & lab
- Bio442 & lab
RESEARCH INTERESTS
All things microbiology! I specialize in antimicrobial peptides, and have many projects exploring the antimicrobial activity of plants found on the island of Oahu.
SELECTED PUBLICATIONS
Positive Selection of Arginine in α-Defensins: Attenuation of Bactericidal Activity by Arg→Lys Substitutions is Dependent on Peptide Primary Structure Infect Immun. 2009 Nov; 77 (11):5035-43.
Weeks CS, Llenado RA, Cocco MJ, Young S, Qu X, and Ouellette AJ
Anionic Amino Acids near the Pro-α-Defensin N-terminus Mediate Inhibition of Bactericidal Activity in Mouse Pro-Cryptdin-4
J Biol Chem. 2009 Mar 13; 284 (11): 6826-21.
Figueredo S, Weeks CS, Young S, and Ouellette AJ
Matrix Metalloproteinase-7 Activation of Mouse Paneth Cell Pro-a-Defensins: Ser43↓Ile44 Proteolysis Enables Membrane Disruptive Activity. J Biol Chem. 2006 Sep 29; 281 (39): 28932-42.
Weeks CS, Hiroki T, Cummings JE, Crampton SP, Sheynis T, Jelinek R, Vanderlick TK, Cocco M, and Ouellette AJ
Structure-Activity Determinants in Paneth Cell a-Defensins: Loss-of-Function in Mouse Cryptdin-4 by Charge-Reversal at Arginine Residue Positions. J Biol Chem. 2004 Mar 19; 279 (12): 11976-83
Tanabe H, Qu X, Weeks CS, Cummings JE, Kolusheva S, Walsh KB, Jelinek R, Vanderlick TK, Selsted ME, and Ouellette AJ.